Fuse has a partnership structure incorporating six universities in the North East and North Cumbria and their policy and practice partners, with a hub at Newcastle University.

The Centre is steered strategically by a Centre Strategy Board and managed by a Centre Management Group and a Research Strategy Group.

Fuse has established two groups to lead on cross-cutting issues that contribute significantly to its mission: the Public Involvement and Engagement Group and the Communications Group. The Fuse Physical Activity Network aims to build research capacity in physical activity related public health research.